Having secured a first league win of the season last time out against Birmingham City, the Whites will be hoping that their confidence boosting victory over the Blues will help them to record their first three points of the campaign on home soil against Sheffield Wednesday.
They are set come up against an Owls side who are yet to pick up maximum points this term, with six draws and four defeats to their name so far - a return which has left them languishing in the Championship's relegation zone.
Victory on Saturday afternoon for Dave Jones' side will see them leapfrog Bolton in the table, while a similar result for Dougie Freedman's men could lift them up two places and close the gap on the teams above them.
The Whites will certainly be wary of the threat which the Owls pose however, with the Hillsborough outfit having secured a 1-0 win at the Reebok in this fixture last season thanks to Mamady Sidibe's first half strike.
Manager Dougie Freedman has a virtually fully fit squad to choose from ahead of the visit of the Owls with Andre Moritz and David Ngog back in contention, but he will continue to be without the services of Mark Davies, Marc Tierney and Stuart Holden who are sidelined with long term injuries.
Sheffield Wednesday make the trip to the Reebok this weekend on the back of a respectable 1-1 draw against Ipswich Town prior to the international break.
Paul Anderson had given the visitors an early lead at Hillsborough, but Michail Antonio's header ensured that Wednesday secured a share of the spoils.
The game however was their sixth stalemate of the campaign, with a win having eluded the Owls so far this season.
After surviving relegation last term by four points, the Yorkshire outfit moved to strengthen their squad with the arrival of a number of new faces in a bid to change the club’s fortunes.
Alongside their summer recruits, this week also saw the signing of Arsenal goalkeeper Damian Martinez on a one-month loan deal, with the 21-year-old Argentine having made two first team appearances for the Gunners so far.
Having joined the club on a one-month loan deal from Hull City in late September, Matty Fryatt looks set to play a key part in what could be a crucial month for the Owls.
After being sidelined for much of last season with an Achilles injury, Tigers’ boss Steve Bruce agreed to send the 27-year-old to Hillsborough in a bid to help him gain match action.
His arrival in Yorkshire however has added some much needed firepower to the Wednesday ranks, with the striker even scoring against Brighton earlier this month.
An experienced frontman, Fryatt started out his career at Walsall before joining Leicester in 2006.
Five successful seasons with the Foxes followed before a move to the KC Stadium in 2011 where he has remained ever since, but his troublesome injury has left him on the fringe of the first team having been pushed down the pecking order in his absence.
Christopher Foy will oversee Saturday’s game against Sheffield Wednesday.
Born in the North West, Foy has refereed three games in the Premier League, one in the Championship and one League One fixture so far this season.
His last outing was just before the international break when he officiated Manchester United’s 2-1 win over Sunderland at the Stadium of Light.
Having handed out 15 yellows and no reds so far, Foy last took charge of a Bolton Wanderers fixture in February when the Whites ran out 2-1 winners over Burnley at the Reebok Stadium.
Sian Massey and Matthew Wilkes will the run the line, whilst the fourth official will be Steven Rushton.