A stunning late strike from Amario Cozier-Duberry ensured Wanderers left the BetWright Stadium with a point to extend their league unbeaten run to seven games.
It was the least that Steven Schumacher's side deserved on an afternoon where they created a number of chances but looked likely to end pointless after Jack Simpson's opener 20 minutes from time.
But an unbelievable leveller from the Brighton loanee in the 94th minute meant that Wanderers headed back to Bolton with another point on the board.
Wanderers came into this game on the back of a six-game unbeaten run and a 3-0 victory over AFC Wimbledon last time out and the team reflected that with an unchanged starting line-up named by Head Coach Steven Schumacher.
The first opening of the game fell Wanderers’ way as a lovely, threaded pass from Max Conway picked out Joel Randall in-behind the defence and through on-goal. Simkin in the Orient goal did well to close down the gap, meaning Joel had to square it looking for Burstow but the home side were able to scramble to clear.
Wanderers continued in the ascendency and another superb pass from George Johnston released Thierry Gale into space down the left. He burst to the byline and tried to cut it back for Aaron Morley to hit first time but Beckles made a big block to deny Aaron getting to the ball.
But the hosts were growing into the counter and after a lucky ricochet allowed him to beat the tackle of Xavier Simons, Jack Moorhouse’s effort was always rising and flew over Teddy Sharman-Lowe’s bar.
As the game edged towards the half-hour mark, a trademark Max Conway run from left-back allowed him to burst into the Orient area untouched. He let fly from the angle but it flew over the crossbar as the half ended goalless.
Wanderers turned defence into attack at the start of the second half, and it was Conway at the heart of it.
First, a superb defensive tackle denied a certain chance for the home side but kickstarted a Wanderers' attack the other way.
Playing a nice one-two with Simons to release the academy graduate into space, who in turn fed Gale into open space down the left. The winger managed to get his shot away that deflected through bodies with Simkin tipping around the post at full stretch.
The game was lively and Gale again had an effort on Simkin’s goal, meeting an Aaron Morley cross from the right with a header when rising above Michael Craig but the Orient keeper was up to the task.
The hosts still threatened, however, and the space opened up for Aaron Connolly to get his strike away from the edge of the area but his effort was never troubling Teddy Sharman-Lowe.
Morley was next to line up a long-range effort from 25 yards when receiving the ball in space from Gale after a lovely cushioned header from Conway started the move, but it whistled just wide of the right-hand post.
Gale was becoming more influential as the second half progressed, and a burst of pace from the Wanderers’ wide player drove him past Rarmani Edmonds-Green and into the area, but could only find the side netting from a tight angle.
Dom Ballard then had a huge opportunity for the home side as a ball in-behind put him one-v-one with Sharman-Lowe but his dinked effort was too powerful and went high over the Wanderers’ keeper’s crossbar.
A goal seemed likely as we approached the final stages, with both sides pushing for the opener and it was Richie Wellens’ men who nudged themselves in front as Jack Simpson fired home from close range after a ball from the right fell his way inside the Wanderers’ area.
The Whites went on the hunt for the equaliser inside the final 20 minutes, and Ethan Erhahon hit a volley sweetly from the edge of the area after Simkin had parried a Conway corner but it flew just wide.
The away side came even closer to getting back on level terms as Sam Dalby played in Cozier-Duberry to allow him to hit a snapshot with his right foot but Simkin made a huge save to turn the ball behind.
Ibrahim Cissoko - introduced into the action in place of Gale - did well to carve out a huge chance for the Whites when getting to the byline and picking out George Johnston with a pull-back to hit first-time, but his goalbound effort came off Simons and away from danger, to Orient's fortune.
With it looking likely that Wanderers would head home with nothing for their performance, their on-loan winger had the final say.
Interchanging passes with Josh Sheehan to cut inside, find a yard and then get his shot away, there was only one place the effort was heading and that was Simkin's top corner as Cozier-Duberry's strike ensured that Schumacher's men got something from the game in another positive performance.
Wanderers: Sharman-Lowe (GK), Dacres-Cogley, Forino, Johnston (C), Conway, Simons, Morley, Cozier-Duberry, Randall, Gale, Burstow.
Subs: Miller (GK), Toal, Sheehan, Erhahon, Cissoko, Forss, Dalby.
Orient: Simkin (GK), Simpson, Happe (C), El Mizouni, Connolly, Mitchell, Craig, Koroma, Edmonds-Green, Moorhouse, Ballard.
Subs: Cahill (GK), James, Beckles, Perkins, Abdulai, Wellens, Clare.