Wanderers hit the road for the first of back-to-back away games as they look to cement their place in the top six.
The Whites play just twice in League One in November so will be bidding to add their points' tally to stay among the play-off pack.
Ian Evatt's men will be seeking a third away win of the campaign against a Cambridge side which made a flying start to the season but which has since slipped to three places and five points above the relegation zone .
Ian Evatt: “It’s an opportunity to progress in the league campaign. I think it is going reasonably well at the moment, so just go and believe in ourselves, play with freedom and hopefully get the result.
“We know Cambridge really well. Mark is a manager that I have a lot of respect for.
“They’re dangerous, especially on their own patch. We always respect the opposition but if we stick to our beliefs and perform then we can be more than a match for anybody in this division.
“First and foremost we have to concentrate on our performance level, get back to the heights of what we were a month or so ago, and win."
Cambridge manager Mark Bonner: “They’ve built a very good squad. January has always been a very big month for them, and the turnaround in their squads, but I think they go into January this year with a much stronger squad than they’ve ever had, and that gives them lots of continuity and options.
“I think we know what to expect from them in terms of the quality of their footballers and the players that they’ve got, but we hope that we can be a competitive match for them.
“We obviously won the game at the Abbey last year, and we’ll be looking to try to do the same again, but we know how difficult that will be.
“I think the reality of the situation is we find ourselves in the league three points lighter than we were after 17 games last season, having had a really tough run of games and fixtures.
“The first ten games put us in a position in the play-offs that was always unrealistic, and I said at the time ‘look at October’s fixtures, I don’t think we’ll be there after 20 games’, and that’s obviously played out that way."
Wanderers will be without midfielder MJ Williams, who serves a one-match ban.
Will Aimson and Lloyd Isgrove are missing with hamstring strains and midfielder Declan John is also unavailable due to illness.
Midfielder Harrison Dunk could earn a start for the U's after returning from more than a month out with injury in last weekend's FA Cup draw at Curzon Ashton.
Wanderers are looking to respond to successive defeats in league and cup following a four-match unbeaten run.
The sixth-placed Whites are aiming to make it back-to-back away wins following a 3-2 victory at Accrington Stanley in their last away game.
Cambridge have slipped down the table to 18th place following a run of just one win in seven League One games.
Mark Bonner’s men have lost the other six in that sequence but did win a Papa Johns Trophy tie against Ipswich and drew 0-0 at National League North side Curzon Ashton last weekend to secure a first-round FA Cup replay.
The U’s have won four and lost four of their home league games so far.
The fixture is Cambridge’s annual Remembrance Fixture and will be officiated by four serving members of the Armed Forces for the first time in an EFL game.
Referee: RAF Sergeant Darren Drysdale
Assistant referees: Army Captain Steve Finch and Army Corporal Declan O'Shea
Fourth official: Royal Navy Petty Officer Scott Jackson
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