Steven Schumacher believes Wanderers can cause Southampton problems when they travel to St Mary's on Saturday (3pm kick-off).
Atsuki Ito, Sam Dalby and Josh Sheehan struck in Tuesday night's 3-1 victory at Molineux, which handed Wolves their first home league defeat of the season and gave Wanderers back-to-back Championship away wins for the first time since August 2018.
Schumacher told Wanderers TV: "I think, obviously, a couple of hours after the Wolves game, once you've got home and you wake up the next morning, your focus is on the next challenge ahead of us, which is a huge one away to Southampton.
"We did a lot of good things right on Tuesday night and we have to try and figure out what we did do well and what was good about our performance, and then try and use that for the next one."
Wanderers sit 14th with 13 points from their opening 10 matches in their first season back in the Championship, five points clear of the bottom three.
Schumacher added: "We were desperate to get to this level, to play in these big games, and when you get the opportunity to play in the games, then there's no point in freezing, playing within yourself.
"I think a lot of players have shown that they are capable of stepping up to the level, and there are also parts of the game that we also understand that we need to get better at, and much better at in some instances.
"It's all part of the journey and we're only 10 games in, but at the moment there are more positive signs, in my opinion, than negative ones."
The Molineux win followed a 4-3 victory at Carrow Road on 20 September, and a third straight away success on Saturday would be the club's first run of three Championship away wins in a row since 2013.
"It's not easy to win a game of football away from home, especially not in this division," said Schumacher. "It shows how well you've got to play, and for us to go to Carrow Road and then to Molineux and score seven goals away from home should give people confidence and belief.
"But just because we've done that twice doesn't mean it's going to happen in the next one and we're really good away from home. It doesn't work like that. You've got to take each game as it comes."
Schumacher acknowledged the quality of Tonda Eckert's side.
"What I've seen of them so far, I think they're the best team in the league," he said.
But he believes Championship opponents give his side more to take advantage of on the road than League One sides did.
He explained: "A lot of teams in League One, when we went away from home, would still be happy with a point last year. There are instances where they don't attack you as much and then it's more difficult for you to break them down.
"Certainly Norwich and Wolves were heavy favourites going into those games, and therefore the incentive is on them to try and come out and attack you. If that is the case, then sometimes there's more for you to take advantage of, and I'm sure that'll be the case on Saturday at St Mary's.
"They'll come and have a go at us. So, if we can defend well enough and hit them on the counter-attack and, as you've seen, cause them problems with our play when we have possession, then we'll be okay."
Team news and travelling support
Schumacher said his squad came through the midweek win in good shape. Defender Chris Forino-Joseph has returned to training, while forward Kyliane Dong has shaken off illness.
"Yeah, we're all okay," said Schumacher. "There's a little bit of tiredness, bits of cramp here and there, a bit of fatigue in one or two of the players, but they've recovered pretty well and they'll be ready to go.
"We're still missing Chris. He's trained today, which was really good. He only trained half of the session today; he didn't do the 11 v 11 bit, but yeah, we're good. We're at full strength, and Kyliane's recovered from his illness, so that's pleasing, too."
Schumacher also paid tribute to the Wanderers supporters who travelled to Molineux on Tuesday night and will make the trip to the south coast on Saturday.
"It was brilliant to me when we looked back and did the review and saw how much it meant to everybody," he said. "The celebrations were amazing, especially after Josh's final goal.
"The fans are outstanding and to do what they did on Tuesday night away from home and then back it up a few days later away from home at Southampton, it's a huge effort. So, we really appreciate it and we'll try putting in a performance that rewards that."
The opposition
Southampton sit seventh with 16 points from 10 games, despite a four-point deduction for breaches of EFL regulations. Saints have won six league matches this season, including all five at St Mary's.
Tonda Eckert's side arrive in form after back-to-back 1-0 wins, at home to Portsmouth on Sunday and away at Norwich City on Wednesday night.
Goalkeeper Gavin Bazunu faces his former club after joining Wanderers from Southampton in the summer.
The clubs have not met in the league since April 2005. Their last meeting came in the League Cup in August 2010, when Wanderers won 1-0 at St Mary's.