Josh Dacres-Cogley returns to the side, replacing Cyrus Christie, making his first appearance in the league since the 1-0 victory over Cardiff City in late October.
The only other change comes in midfield as Xavier Simons comes in for the suspended Josh Sheehan. The summer signing returns to the starting XI after a 20 minute cameo off the bench last weekend against Bradford.
Ethan Erhahon is amongst the substitute's bench, making a return to the matchday squad following a thigh injury in training in early October.
Wanderers will be backed by a sold-out away crowd of over 1,300 travelling Whites at Kenilworth Road this afternoon.
Wanderers: Sharman-Lowe, Dacres-Cogley, Johnston, Toal, Conway, Osei-Tutu, Morley, Simons, Cozier-Duberry, Dempsey, Burstow
Subs: Miller, Taylor, Erhahon, Cissoko, Forss, McAtee, Dalby
Luton Town: Keeley, Bramall, Odoffin, Lonwijk, Mengi, Naismith, Saville, Walsh, Fanne, Brown, Yates
Subs: Shea, Andersen, Alli, Morris, Makosso, Kodua, Nelson
Referee: Ruebyn Ricardo