Xavier Simons gets his first taste of Championship football with Wanderers as boss Steven Schumacher makes three changes for the trip to Bramall Lane.
Simons comes into the midfield after completing a three-match ban for his sending off in the Steel City against Sheffield Wednesday in the Carabao Cup.
Former Sheffield United loanee Ben Davies also starts a league game for the first time for the Whites, with Gaizka Larrazabal also returning in a new-look back line.
Ruben Rodrigues returns from injury on the bench as Steven Schumacher's men look to bounce back from a first Championship defeat to Lincoln City last Saturday.
The unbeaten hosts include new signings Hamza Choudhury and Ben Brereton Diaz as they look for a first league win of the campaign.
Wanderers: Bonham, Forino, Simons, Davies, Sheehan, Dalby, Famewo, Iling-Junior, Larrazabal, McAtee. Substitutes: Bazunu, Brunt, Dong, Toal, Rodrigues, Erhahon, Conway, Nelson, Hardie.
Sheffield United: Cooper, McCallum, Tanganga, Choudhury, Donovan, Brereton Diaz, Campbell, McGuinness, Peck, Riedewald, Bamford. Substitutes: Davies, Doherty, Arblaster, Rothwell, Cannon, Shackleton, Phillips, Norrington-Davies, Baptiste
Referee: Tony Harrington