Wanderers make three changes for only their second home league game this year.
Josh Sheehan misses out through injury and Mason Burstow and Chris Forino are also absent from the side that started Tuesday night’s 0-0 draw at Stevenage.
Midfielder Ethan Erhahon returns, along with wideman Thierry Gale, and John McAtee starts for just the second time in League One this season.
Winger Ibrahim Cissoko is back among the substitutes as the Whites look for a ninth home league win of the campaign to firm up their place in the top six.
Leyton Orient - 16th in the table after a first win in five games a week ago - are without former Wanderers’ defender Will Forrester who misses out on a quick return to the Toughsheet Community Stadium through injury.
Wanderers: Bonham, Simons, Johnston, Dalby, Gale, Osei-Tutu, Toal, Cozier-Duberry, Erhahon, Conway, McAtee. Substitutes: Harrington, Forino, Morley, Cissoko, Dempsey, Christie, Burstow.
Leyton Orient: Cahill, James, Simpson, O'Neill, Mitchell, Bakinson, Casey, Abdulai, Wellens, Barrard, Archibald. Substitutes: Phillips, Happe, Matthews, Craig, Koroma, Perkins, Moorhouse.
Referee: Sebastian Stockbridge