George Thomason returns to captain the side as Wanderers bid to reach the semi-finals of the Vertu Trophy.
Thomason is able to play in between his two-match league ban and is one of seven players coming into Steven Schumacher's starting line-up following Saturday’s win over Crawley Town.
Birthday boy Jay Matete also starts with Wanderers – winners of the competition in 2023 – missing the cup-tied trio of Aaron Morley, Joel Randall and Alex Murphy and the suspended Szabi Schön.
Aaron Collins – top scorer in this season’s competition – returns from injury to start on the bench alongside two members of the Whites’ B Team squad.
League One rivals Wrexham, playing their first game since beating Port Vale in the last round a week ago, include new striker signings Jay Rodriguez and Sam Smith on the bench.
The winners of tonight’s tie, which will go straight to penalties if the scores are level after 90 minutes, will be at home to Peterborough United in the last four.
Wanderers: Baxter, Jones, Thomason, Johnston, Sheehan, Adeboyejo, Dacres-Cogley, Forrester, Lolos, Toal, Matete. Substitutes: Southwood, Inwood, Sharples-Ahmed, Osei-Tutu, Andreucci, McAtee, Collins.
Wrexham: Okonkwo, Brunt, Scarr, O'Connor, Longman, Evans, Cannon, Lee, Revan, Marriott, Faal. Substitutes: McNicholas, Cleworth, Mendy, Rathbone, Barnett, Smith, Rodriguez.
Referee: Ross Joyce